Asian Spine J Search

CLOSE


Asian Spine J > Online first
Duong, Tuan, Son, Bao, Thanh, and Liawrungrueang: Clinical and radiological outcomes of biportal endoscopic posterior cervical foraminotomy: a single-center retrospective cohort study with 1-year follow-up

Abstract

Study Design

Retrospective single-center cohort study.

Purpose

To evaluate 1-year clinical and radiological outcomes of biportal endoscopic posterior cervical foraminotomy (BE-PCF) in cervical spondylotic radiculopathy (CSR).

Overview of Literature

CSR is commonly managed with anterior cervical discectomy and fusion, cervical disc replacement, or posterior cervical foraminotomy. However, these approaches may lead to fusion-related complications, prosthesis degeneration, or posterior tension band disruption. Minimally invasive techniques, such as biportal endoscopic spine surgery, aim to reduce tissue damage while maintaining effective decompression. Long-term outcome data for BE-PCF remain limited.

Methods

Twenty-one patients (31 levels) who underwent BE-PCF (June 2023–December 2024) were retrospectively analyzed. Clinical outcomes included Visual Analog Scale (VAS) scores for neck and arm pain and Neck Disability Index (NDI) at baseline, discharge, 6 months, and 1 year. Radiological outcomes were assessed using dynamic radiographs (C2C7 and segmental range of motion [ROM]) and computed tomography (CT) at 6 months, evaluating facet resection, foraminal diameter, and approach angle.

Results

Mean follow-up was 14.8±6.7 months. VAS and NDI improved significantly (p<0.001). Neck pain decreased from 6.9±1.1 to 2.5±0.7, arm pain from 8.1±0.7 to 2.0±0.6, and NDI from 30.8±3.6 to 12.2±1.6. Cervical ROM was preserved (C2C7: 40.5°±10.1° vs. 40.5°±10.3°, p=0.99; segmental: 13.1°±4.4° vs. 13.8°±5.7°, p=0.18). CT demonstrated significant foraminal enlargement (mid-foraminal: 4.2±0.8 to 6.5±1.0 mm; distal: 3.7±1.1 to 4.8±1.0 mm; both p<0.001). Mean facet resection was 34.6%±7.7%, with no case exceeding 50%. Complications included transient C5 palsy (4.7%) and one wrong-level surgery (3.2%).

Conclusions

BE-PCF is a safe and effective minimally invasive option for CSR, providing significant clinical improvement, preserved cervical motion, and adequate decompression with low complication rates at 1 year.

Introduction

Cervical spondylotic radiculopathy (CSR) is a common disorder of the cervical spine associated with significant functional impairment [1,2]. The condition is primarily caused by mechanical compression of the cervical nerve roots, most frequently due to intervertebral disc herniation, osteophytes arising from the intervertebral disc, facet joint degeneration, or a combination of these factors. The resultant compression may manifest as neck and shoulder pain, sensory disturbances, including numbness or radicular pain along the affected dermatome, and occasionally as motor weakness. Surgical treatment of CSR offers favorable outcomes; various surgical techniques using anterior or posterior approaches have been described for CSR, each with distinct advantages and disadvantages [37].
For decades, conventional anterior approaches have been extensively studied, with anterior cervical discectomy and fusion (ACDF) and cervical disc replacement (CDR) considered as standard surgical options [3,8]. While ACDF provides reliable decompression, it inevitably results in fusion, reducing the range of motion (ROM) and predisposing patients to adjacent segment disease [9]. CDR offers a motion-preserving alternative; however, prosthesis degeneration over time remains a substantial concern, which may ultimately lead to secondary fusion [10]. Posterior cervical foraminotomy (PCF), with or without discectomy, represents another motion-preserving option. Since its first description in 1944, PCF has consistently shown favorable outcomes, and several studies have reported clinical results comparable to anterior techniques [11,12]. Nevertheless, disruption of the posterior tension band (PTB), including ligaments and paraspinal muscles, in PCF is associated with postoperative instability and a relatively high incidence of persistent axial neck pain, highlighting a significant drawback of this technique [5,8].
Recently, minimally invasive spine surgery (MISS) has emerged as an effective alternative to address these limitations; it is aimed at preserving the anatomical structures, promoting faster recovery, and reducing long-term complications. Among these, biportal endoscopic spine surgery (BESS) has been widely adopted for degenerative spinal disorders [13,14]. BESS employs separate working and viewing portals providing a magnified surgical field and greater instrument maneuverability, and allowing precise decompression while minimizing surrounding tissue injury. Building on the favorable results achieved in the lumbar spine, the fundamental principles of BESS have been increasingly refined and extended to more technically demanding regions, including the thoracic and cervical spines [13,15].
Early investigations using biportal endoscopic-PCF (BE-PCF) have demonstrated favorable clinical outcomes, particularly in terms of symptomatic improvement, such as pain reduction and functional recovery, with relatively low complication rates [1517]. However, most of these studies have been limited by short follow-up durations or a lack of comprehensively evaluated radiological parameters, such as facet joint preservation, global and segmental cervical ROM, and postoperative cervical spine stability. Consequently, the robustness of these outcomes and radiological parameters remains undefined. Therefore, the present study aims to evaluate the clinical and radiological outcomes of BE-PCF at the 1-year follow-up to elucidate its efficacy and safety.

Materials and Methods

In this single-arm retrospective cohort study, we included patients who underwent BE-PCF for CSR between June 2023 and December 2024. The study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Ethics Committee and Institutional Review Board of Xuyen A General Hospital Medical Research Council (approval number: NCKH-27/2025/QD-BVXA). Written informed consent was obtained from all individual participants included in the study.

Inclusion and exclusion criteria

Patients were included if they had: (1) a confirmed diagnosis of CSR at one or two levels and presented with persistent upper extremity radicular pain, with or without motor weakness; (2) magnetic resonance imaging evidence of cervical foraminal stenosis caused by factors such as disc herniation, intervertebral disc osteophytes, or facet joint hypertrophy, consistent with clinical symptoms; and (3) failure of at least 6 weeks of conservative treatment. Exclusion criteria were (1) segmental instability demonstrated on flexion–extension radiographs; (2) cervical canal stenosis causing cervical spondylotic myelopathy; or (3) other concomitant conditions, such as infection, trauma, or tumors.

Surgical procedure

Anesthesia and patient position

The patient was placed under general endotracheal anesthesia in the prone position on a Wilson frame (Fig. 1A). A radiolucent spine table was used, and the table height was adjusted to facilitate fluoroscopic imaging in both anteroposterior (AP) and lateral views. The patient’s head was securely fixed in a neutral position using adhesive tape, while both shoulders were firmly held and maximally pulled caudally to allow clear visualization of the lower cervical vertebrae on lateral fluoroscopy (Fig. 1B, C). The surgeon stood on the symptomatic side of the patient.

Skin incisions and working space

First, the surgical level was confirmed using fluoroscopic images in both AP and lateral views to identify the target point, which in this case was the cranial lamina; this allowed the dilators to rest safely on bony structures while creating the working space. In the AP view, an approximately 1.5-cm long transverse skin incision was made at the level of the inferior border of the caudal pedicle for the working portal (Fig. 2A). After adequate fascial opening, serial dilators were advanced through this incision to detach the paraspinal muscles and reach the cranial lamina. Larger dilators inserted toward the cranial lamina were gradually directed laterally from the midline, ensuring constant bony contact to maintain safety (Fig. 2B).
Next, the skin incision for the scope portal was made approximately 3 cm cranial to the working portal incision when approaching from the left side. Smaller dilators were used to establish triangulation, with the distal contact point positioned near the inferior margin of the cranial lamina. Once true triangulation was achieved and the optimal working corridor was confirmed, the surgical level was established on the lateral fluoroscopic view (Fig. 2C).

Foraminotomy and decompression

We employed a standard BE instrument set with a 0° scope, supplemented by a fine 0.8-mm RF probe and a 1.5-mm curved curette (Fig. 1D). A saline bag was positioned approximately 30 cm above the patient’s neck to secure a stable inflow and outflow system and ensure continuous irrigation. From the cranial lamina, a bipolar RF probe (Arthrocare, Austin, TX, USA) was used to gently clear soft tissues and expose the V-point, defined as the junction of the superior and inferior laminae and the medial facet joint (Fig. 3A1, 3B1). At the same time, the interlaminar space and caudal lamina were also identified.
Before initiating bony decompression, fluoroscopic confirmation was routinely performed in both AP and lateral views to verify the surgical level and the position of the V-point. This step was essential, as even small shifts of the instruments within the narrow cervical interlaminar space could result in the wrong spinal level. A high-speed 3-mm diamond burr (NKS Primado2; Nakanishi Inc., Kanuma, Japan) was then used to drill from the V-point, extending cranially and caudally along the lamina, to gradually enlarge the foramen (Fig. 3A2, 3B2). The burr diameter served as a guide for the extent of bone removal; the medial limit of the foraminotomy was determined when the lateral edge of the ligamentum flavum was exposed. As the bony foramen was progressively thinned, the contour of the exiting nerve root became visible. Final decompression was achieved along the nerve root trajectory, and the residual thin bony was removed with a 1.5-mm curved curette.
Because the cervical nerve root is usually enveloped by a venous plexus, meticulous hemostasis was achieved using the RF probe at the lowest possible energy setting to maintain a clear operative field. In selected cases, partial pediculotomy was performed with a high-speed 2-mm diamond burr to achieve sufficient decompression. This maneuver required the biportal two-handed technique, in which a beveled trocar was placed outside the endoscope to provide dynamic retraction and shielding of the neural elements (Fig. 3A3, 3B3). Adequate decompression was confirmed when the nerve root was freely mobilized, and dural pulsation was clear (Fig. 3A4, 3B4).

Wound closure and postoperative management

Meticulous hemostasis was achieved using the RF probe and Floseal before performing layered wound closure. Postoperatively, patients were placed in a 20° head-elevated position and fitted with a soft cervical collar. Drainage tubes were removed, and early mobilization was encouraged on the first postoperative day. In addition to wound and drain monitoring, patients were put under carefully observation to detect signs of increased intracranial pressure, with particular attention to patients presenting with postoperative hypertension that was difficult to control.

Outcome measures

Clinical outcomes were evaluated using the Visual Analog Scale (VAS) for neck pain and radicular pain, as well as the Neck Disability Index (NDI) for functional assessment. These scores were collected preoperatively, at discharge, at the 6-month follow-up, and at the final (1-year) follow-up.
Radiological outcomes were assessed by comparing flexion–extension radiographs and cervical spine computed tomography (CT) scans obtained preoperatively and 6 months postoperatively. On radiographs, the global C2–C7 ROM and segmental ROM were measured. On CT scans, the following parameters were evaluated: facet length (FL), mid-foraminal diameter (MFD), distal-foraminal diameter (DFD), and foraminal approach angle (FAA). All measurements were performed by independent evaluators who were blinded to the study design to minimize bias.

Statistical analysis

All analyses were performed using STATA ver. 17.0 (Stata Corp., College Station, TX, USA). Continuous variables were expressed as mean±standard deviation, whereas categorical variables were reported as frequencies and percentages. Given the modest sample size, the normality of continuous variables was assessed using the Shapiro-Wilk test. Accordingly, preoperative and postoperative clinical outcomes (VAS for neck pain, VAS for radiating arm pain, and NDI) were compared using paired-sample t-tests or Wilcoxon signed-rank tests based on the normality of data distribution. Subgroup comparisons of categorical variables, such as left-sided versus right-sided approaches, were conducted using chi-square tests. A p-value of <0.05 was considered statistically significant.
To assess whether the study was sufficiently powered to detect clinically meaningful changes, a post hoc power analysis was performed based on the observed effect sizes of the primary clinical outcomes. Cohen’s d values were calculated for paired differences in VAS and NDI to quantify the magnitude of treatment effects.

Results

Patient demographics

A total of 21 patients with CSR with 31 affected levels (mean age: 55.4±12.4 years; range, 37–80 years; males: n=11/21 [52.4%]) were treated with BE-PCF during the study period. The average follow-up duration was 14.8±6.7 months (range, 7–25 months). The mean body mass index of the cohort was 23.7±1.6 kg/m2 (range, 20.6–26.7 kg/m2). Comorbidities, such as diabetes mellitus, hypertension, chronic obstructive pulmonary disease, congestive heart failure, and previous cerebral infarction, were present in 66.7% of cases, whereas osteoporosis was identified in 38.1%. Regarding preoperative symptoms, 71.4% of patients reported sensory disturbances alone, whereas 28.6% presented with both sensory and motor deficits (Table 1).

Perioperative findings

The primary indications for BE-PCF were foraminal stenosis with osteophytes at 13 affected levels (42.0%), cervical disc herniation at nine levels (29.0%), and combined osteophytes with disc herniation in the other nine cases (29.0%). The most frequently operated level was C5–C6 (58.1%), followed by C4–C5 (19.4%), C6–C7 (12.9%), and C3–C4 (9.6%). In terms of the affected side, 16 cases (51.6%) were operated on the left side and 15 (48.4%) on the right side. Regarding surgical extent, 11 patients (52.4%) underwent single-level decompression, whereas 10 patients (47.6%) had two-level procedures. The mean operative time per level was 79.8±27.5 minutes (range, 45–120 minutes), with an average intraoperative blood loss of 140.5±48.1 mL (range, 100–250 mL). The mean length of hospital stay was 5.2±1.8 days (range, 3–10 days). Perioperative complications were minimal, with one case (3.2%) of wrong-level exposure recorded; one patient (4.7%) experienced a transient neurological deficit, while there were no cases of dural tear or infection (Table 2).

Clinical outcomes

All pre- and postoperative VAS and NDI scores were normally distributed (p>0.05), supporting the use of paired t-tests for all pre- and postoperative comparisons. Patients showed significant improvements in both pain and functional scores following BE-PCF (Table 3); the mean VAS scores for neck pain decreased from 6.9±1.1 preoperatively to 3.1±0.7 at discharge, 2.6±0.6 at 6 months, and 2.5±0.7 at the last follow-up (p<0.001). Similarly, mean VAS scores for radiating arm pain improved from 8.1±0.7 preoperatively to 2.6±1.1 at discharge, 2.3±0.7 at 6 months, and 2.0±0.6 at the final follow-up (p<0.001). The NDI scores also decreased from 30.8±3.6 preoperatively to 15.5±2.0 at discharge, 12.8±3.7 at 6 months, and 12.2±1.6 at the last follow-up (p<0.001).
In the post hoc power analysis, the paired differences demonstrated very large effect sizes for all three outcomes (Cohen’s d: VAS for radiating arm pain=5.65, VAS for neck pain=3.92; NDI=5.48). Using these effect sizes with the available sample size (n=21) and α=0.05, the estimated statistical power was computed as 1.000 for all outcome measures, confirming the power of the analysis despite the modest cohort size.

Radiological outcomes

Radiographic assessment showed that the global cervical ROM remained unchanged in the entire cohort (40.5°±10.1° preoperatively vs. 40.5°±10.3° postoperatively, p=0.99). Likewise, segmental ROM also showed no significant difference between pre- and postoperative values (13.1°±4.4° vs. 13.8°±5.7°, p=0.18). CT imaging demonstrated significant bony changes; FL decreased from 13.5±1.6 preoperatively to 8.7±1.3 mm postoperatively (p<0.001). The mean facet resection rate was 34.6%±7.7%, and importantly, no cases exceeded 50% facet removal. The foraminal dimensions were significantly expanded, with the MFD increasing from 4.2±0.8 to 6.5±1.0 mm (p<0.001) and the DFD increasing from 3.7±1.1 to 4.8±1.0 mm (p<0.001) (Table 4).
When radiologic changes were compared between sides, there were no statistically significant differences. The mean facet resection rate was 35.9%±6.4% on the left side and 33.3%±8.9% on the right (p=0.35). The MFD expansion rate was 60.4%±34.1% overall (57.1%±41.9% on the left vs. 63.9%±23.9% on the right side, p=0.58), whereas the DFD expansion rate was 34.7%±27.5% overall (38.3%±31.1% on the left vs. 30.8%±23.5% on the right side, p=0.46). The mean FAA was 9.5°±2.5° overall, with no significant side-to-side difference (8.8°±2.0° on the left vs. 10.2°±2.9° on the right, p=0.13) (Table 5).

Discussion

CSR is a common degenerative disorder that presents with neck pain, radicular numbness, and, in some cases, motor deficits [1,2,7]. Although many patients respond to conservative treatment, surgery remains the preferred approach for those with persistent symptoms or neurological impairment [57]. The existing techniques, ACDF, CDR, and PCF, have demonstrated comparable clinical efficacy for treating CSR [3,8,18], yet each carries specific limitations. ACDF results in fusion and may lead to adjacent segment disease [9]. CDR can lead to the development of heterotopic ossification in the long term [10], and PCF may cause postoperative instability and persistent axial neck pain due to disruption of the PTB [11,19,20]. The increasing use of MISS has helped achieve favorable clinical results while addressing the limitations of these conventional procedures [18,21]. BESS was originally introduced for the lumbar spine to offer enhanced visualization, flexible instrument maneuverability, and a true two-handed working environment [13,14]. Based on the encouraging results with BESS reported across various degenerative spinal conditions, this approach was gradually extended to thoracic and cervical pathologies [13].
Early reports documented the clinical effectiveness of BE-PCF for managing CSR [13,14]. As clinical experience with BE-PCF has grown, there is strong evidence corroborating its effectiveness and safety [16,17,21,22], with studies reporting favorable outcomes, low complication rates, and preservation of motion. Heo et al. [16] introduced the “sliding technique” for two adjacent levels, enabling multilevel decompression without the need for additional skin incisions or repeated creation of working portals. A meta-analysis by Lee et al. [17] confirmed that BE-PCF provides outcomes comparable to full-endoscopic PCF, further supporting its safety profile with a reported complication rate of only 6%–8%. Further, Kim et al. [21] demonstrated that uniportal, biportal, and microscopic PCF achieve equivalent midterm clinical results, with endoscopic approaches offering the added advantage of superior facet joint preservation.
Our findings are consistent with previous reports, demonstrating that BE-PCF is effective for both single- and two-level lesions, and can be safely applied to selected cases requiring bilateral decompression at the same level (Table 2). The relatively short operative time, minimal blood loss, and brief hospital stay make this technique particularly valuable for elderly patients with comorbidities, a population in which CSR is highly prevalent. In addition, BE-PCF was found to be effective across different etiologies of CSR, including disc herniation, osteophytic foraminal narrowing, and facet joint degeneration. Beyond indirect decompression achieved through foraminal enlargement, the biportal two-handed technique with a beveled trocar allows direct removal of offending structures, such as extruded disc fragments or bony overgrowth at the vertebral margin, which are common sources of nerve root compression.
In addition to statistical significance, the clinical relevance of postoperative improvement can be interpreted in the context of the minimal clinically important difference (MCID). Previous studies on cervical spine pathologies have proposed MCID thresholds of approximately 2.6 points for VAS-neck pain, 4.1 points for VAS-arm pain, and 17.3% for the NDI using anchor-based and minimum detectable change approaches [23]. In the present study, the magnitude of improvement observed in VAS and NDI scores exceeded these MCID threshold values, suggesting that the clinical benefits of BE-PCF 1 year after the surgery were not only statistically significant but also likely to be clinically meaningful.
These favorable outcomes were reinforced by the low complication rates with this technique; however, several technical precautions are essential to prevent undesirable events. Only one patient (4.7%) developed transient C5 palsy during the early learning phase, which was likely related to excessive RF use near the nerve root. The deficit fully recovered within 3 months, underscoring the importance of applying RF at the lowest energy setting, intermittently rather than continuously, and with caution around neural structures. Additionally, there was one case of wrong-level surgery (3.2%), which underscores the critical importance of accurate cervical level identification. In this case, the patient was scheduled for left-sided BE-PCF at C4–C5 and C5–C6, but the initial decompression was inadvertently performed at C6–C7. The error was promptly recognized when intraoperative fluoroscopy was repeated before proceeding to the next level, allowing the surgery to continue at the correct levels without further complications. This risk is explained by the small size of the cervical lamina and the narrow interlaminar spaces in the cervical spine, which place the vertebral levels in close proximity and make even minor instrument shifts likely to result in wrong-level surgery. To minimize this risk, we recommend marking the V-point and reconfirming the exact level with both AP and lateral fluoroscopy before bony drilling.
Another important safety consideration in cervical biportal endoscopic surgery is the management of irrigation dynamics, as improper fluid handling may lead to elevated epidural pressure and, in extreme situations, increased intracranial pressure [17,24]. Previous studies have demonstrated that cervical epidural pressure can transiently rise during endoscopic decompression, particularly when outflow is obstructed; however, these elevations, typically ranging from 30–45 mm Hg, are not associated with neurological injury [17]. Thus, maintaining an unobstructed inflow–outflow pathway is critical to ensuring a stable and safe operative environment [24]. Additionally, adequate fascial release and continuous monitoring of visualization quality help prevent pressure buildup within the surgical chamber [13,24]. Based on these principles, we maintained an irrigation pressure of <30 mm Hg throughout the procedure to minimize the risk of epidural hypertension, cervical spinal cord compression, or intracranial hypertension.
Revision surgery rates following conventional PCF may be higher than those after ACDF, although the magnitude of this difference remains inconclusive [12]. However, the 1-year follow-up data in our study confirmed the efficacy and safety of BE-PCF; no revision surgeries were required for recurrent radiculopathy or procedure-related instability during the observation period. Dynamic radiographs further demonstrated preservation of both global cervical and segmental ROM, underscoring the motion-preserving benefits of this procedure. This finding is particularly relevant as conventional PCF has been associated with postoperative ROM reduction, especially in multilevel cases [25,26]. Lee et al. [26] reported that nearly half of patients experienced segmental ROM loss >2°, with higher preoperative flexion angles and advanced disc degeneration predisposing to postoperative ROM loss in conventional PCF and even bony bridge formation, which may contribute to persistent neck pain and impaired quality of life. On the other hand, microscopic PCF has been linked to greater kyphotic changes and a higher risk of instability, whereas the BE-PCF can preserve dynamic motion without evidence of instability [25]. Furthermore, the motion-preserving outcomes with BE have been observed not only in ipsilateral BE-PCF (as demonstrated in our study), but also in contralateral BE-PCIF, as described by Song and Kim [27]. Among the two approaches, the ipsilateral technique appears particularly advantageous, offering a familiar surgical view similar to that of open or microscopic surgery and providing more direct access to foraminal structures. The contralateral approach requires crossing the foramen and may carry additional risks to the dura and spinal cord. Furthermore, the learning curve for BE-PCF is relatively short, with technical competency reported after approximately 20 cases [15].
A fundamental principle underlying PCF is to achieve sufficient foraminal decompression to relieve nerve root compression while preserving as much of the facet joint as possible, since resection of more than 50% of the facet area has been shown to increase the risk of segmental instability [28,29]. So far, only a few studies have evaluated postoperative CT to quantify facet preservation [21,27,29]. In our study, standardized CT performed at 6 months postoperatively demonstrated that no case exceeded 50% facet resection, highlighting the extent of precision achievable with BE-PCF. The magnified endoscopic view allowed targeted decompression around the V-point without the need for excessive bony resection. Moreover, the independent working portal facilitated the creation of an inclining drilling trajectory aligned with the exiting nerve root to ensure adequate distal-foraminal decompression as well as limit unnecessary facet removal (Fig. 4). This inclinatory angle could be achieved through the independent working portal using a diamond burr and curved curettes, progressing from the medial to the lateral direction on the ipsilateral side. Consistent with previous reports [21,27], we found that a larger FAA directed laterally correlated with greater decompression of the distal foramen while still maintaining facet preservation. This highlights a key technical advantage of the BE-PCF approach, where ipsilateral access provides both a familiar surgical orientation and sufficient lateral working space to safely expand the foramen with minimal impact on facet stability. When radiological outcomes were compared between left-sided and right-sided procedures performed with the working portal positioned caudally on the left or cranially on the right for a right-handed surgeon, no significant differences were observed across any measured parameters. This suggests that the efficacy and safety of BE-PCF are not influenced by the surgical side, even when the orientation of the working portal is adjusted according to the surgeon’s handedness (Fig. 5).
In summary, BE-PCF is a safe and effective option for managing CSR, delivering favorable clinical and radiological outcomes at 1-year postoperatively, particularly regarding cervical motion preservation and limited facet resection. Nevertheless, there were several limitations to this study that should be acknowledged. First, this was a retrospective cohort study with a relatively small sample and a 1-year follow-up; hence, our findings may be affected by selection and reporting biases. Second, the study was conducted at a single center, and all procedures were performed by a single spine surgeon, which may limit the generalizability of the findings, particularly regarding the complication rates. Cervical biportal endoscopic procedures are widely considered an advanced step in the MISS learning curve, requiring substantial prior experience with lumbar and thoracic endoscopic techniques to ensure a thorough understanding of irrigation dynamics, visualization, and neural safety [13,15,30]. Therefore, the operative efficiency, complication profile, and accuracy of facet preservation observed in this series may reflect the operating surgeon’s prior experience and may not be directly reproducible during the early learning phase of BE-PCF. Third, the absence of a control group for comparison, particularly with established anterior procedures such as ACDF or CDR, or posterior approaches including microscopic PCF, and endoscopic uniportal techniques, represents a major limitation. Each of these techniques carries its inherent shortcomings, many of which are closely related to long-term sequelae, such as adjacent segment degeneration, postoperative cervical ROM reduction, or symptom recurrence. Because these adverse events often require extended follow-up to be fully assessed, the lack of a comparator cohort prevented us from determining whether the favorable outcomes observed with BE-PCF in this study translate to superior long-term durability relative to other surgical options. Nevertheless, our findings underscore the ability of BE-PCF as a motion-preserving, minimally invasive technique, serving as preliminary evidence for future research. Larger comparative studies with longer follow-up periods, systematic reviews, and meta-analyses are warranted to better delineate the relative benefits and long-term implications of BE-PCF within the broader landscape of CSR. Fourth, although VAS and NDI are widely used practical tools for assessing pain and functional disability, they provide only a limited view of overall patient health status; the absence of broader patient-reported outcome measures, such as the 36-Item Short Form Health Survey or the EuroQol-5 Dimension, restricts our ability to evaluate global quality-of-life improvements following BE-PCF. Future studies should incorporate these multidimensional instruments to comprehensively assess postoperative outcomes.

Conclusions

BE-PCF is a safe and effective minimally invasive option for treating CSR; it provides adequate foraminal decompression and offers significant clinical improvement, while preserving cervical ROM, as observed at the 1-year follow-up. The technique used in this study was feasible for both single- and two-level lesions, including selected bilateral cases, and may be beneficial for elderly patients with comorbidities. Nevertheless, given the retrospective design, limited sample size, and relatively short follow-up duration, further multicenter studies with larger cohorts and longer follow-up are required to confirm these findings regarding the role of BE-PCF in CSR management.

Key Points

  • Key Point 1: Biportal endoscopic posterior cervical foraminotomy (BE-PCF) provides significant clinical improvement with low complication rates at 1-year postoperatively, confirming the durability of these outcomes.

  • Key Point 2: Radiological evaluation with dynamic radiographs demonstrated preserved cervical range of motion (both global and segmental) post-operatively.

  • Key Point 3: Postoperative computed tomography at 6 months confirmed facet preservation (<50% resection), effective mid- and distal-foraminal enlargement, and highlighted the inclinatory decompression angle.

Data Availability

The data used in this research were acquired from a public resource.

Notes

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Author Contributions

Conceptualization: TVHD, PAT, PQS, WL. Methodology: TVHD, PAT, PQS. Data curation: TVHD, PAT, LTB, PDT. Formal analysis: TVHD, PAT, LTB, PQS, PDT. Visualization: TVHD, PAT, PQS. Project administration: TVHD, PAT. Writing–original draft preparation: TVHD, PAT, WL. Writing–review and editing; TVHD, PAT, WL, PQS. Supervision: TVHD, PAT. Final approval of the manuscript: all authors.

Fig. 1
(A) Patient positioned prone on a Wilson frame with a radiolucent table allowing both anteroposterior and lateral C-arm imaging. (B) The head is securely fixed with adhesive tape and both shoulders are pulled caudally to optimize visualization of the lower cervical spine. (C) General surgical field prepared and isolated with waterproof drapes. (D) Surgical instruments arranged from left to right: nerve root hook, straight forceps, curved forceps, curved micro-spatula for dissecting periradicular vessels, 2-mm Kerrison punch, 1-mm Kerrison punch, 1.5-mm curved curette, NSK high-speed drill with a 2-mm diamond burr, RF coagulator, and Arthrocare bipolar probe. Written informed consent for the publication of this image was obtained from the patient.
asj-2025-0626f1.jpg
Fig. 2
Step-by-step determination of skin incisions for two portals and creation of the working space. (A) Illustration of left-sided biportal endoscopic-posterior cervical foraminotomy at C5–C6: the working portal (red line) is a 1.5 cm transverse incision, placed 1.5 cm lateral to the midline at the level of the inferior border of the C6 pedicle, targeting the inferior lamina of C5 (red circle). The scope portal (blue line) is positioned 2.5–3 cm cranial to the working portal. (B) Sequential insertion of dilators through both portals to achieve true triangulation, with distal tips contacting the C5 lamina near the target point. “True triangulation” is defined as the geometric configuration in which the working and viewing channels converge and contact at their distal tips at the inferior border of the lamina, thereby enabling a stable two-handed endoscopic working environment. (C) Schematic illustration showing lateral C-arm fluoroscopy confirming dilator positioning. (D) Surgical field overview with dilators placed in both portals. (E) Anteroposterior fluoroscopic confirmation. (F) Lateral fluoroscopic confirmation.
asj-2025-0626f2.jpg
Fig. 3
Schematic illustrations (A) and corresponding endoscopic views (B) demonstrating the step-by-step process of foraminal decompression. (A1, B1) Identification of the V-point after soft tissue clearance. The “V-point” is defined as the anatomical junction of the superior lamina, inferior lamina, and medial facet. (A2, B2) Initial foraminotomy performed using a 3-mm diamond burr, enlarging the foramen to approximately 3 times the burr diameter. Decompression proceeds along an inclinatory decompression angle, referring to an oblique drilling direction oriented toward the neural foramen to minimize facet joint violation. Drilling is extended from the V-point with partial facet resection until thinning of the foraminal wall allows visualization of the exiting nerve root. The medial limit of decompression is exposure of the lateral margin of the ligamentum flavum. (A3, B3) In selected cases requiring removal of herniated disc fragments or hypertrophic bone from the vertebral body, partial pediculotomy is performed. A beveled trocar is used outside the scope to retract the nerve root, while careful drilling with a 2-mm burr provides additional working space. (A4, B4) Final view of the decompressed nerve root within the foramen, surrounded by peri-radicular vessels.
asj-2025-0626f3.jpg
Fig. 4
Radiological outcome assessments. (A–D) Measurements on pre- and postoperative computed tomography scans at the same axial level. Facet length (a, a′) and mid-foraminal diameter (b, b′), defined as the distance between the medial margin of the superior articular process and the vertebral body; distal-foraminal diameter (c, c′), defined as the distance from the vertebral body to a line drawn 2 mm lateral to the uncovertebral joint (black dashed line); foraminal approach angle (γ), measured between two imaginary lines: one connecting the resected facet joint surface and another parallel to the sagittal midline (white dashed line). (E, F) Measurements on dynamic X-rays: global cervical range of motion (ROM), calculated as the sum of Cobb angles of C2–C7 in flexion (α) and extension (β); and segmental ROM, calculated as the sum of Cobb angles at the operative level in flexion (α′) and extension (β′).
asj-2025-0626f4.jpg
Fig. 5
Illustration of a representative case. A 42-year-old male presented with neck pain and left-sided C5 and C6 radicular numbness, with a preoperative radicular Visual Analog Scale score of 8. (A–D) Preoperative magnetic resonance imaging and computed tomography (CT) scans show left foraminal stenosis at C4–C5 and C5–C6 (white circles), caused by disc herniation and osteophytes from the vertebral body (red arrows). (E, F) Postoperative CT and three-dimensional reconstruction demonstrate adequate foraminal enlargement (white arrows).
asj-2025-0626f5.jpg
Table 1
Patient demographics
Characteristic Measurement value
No. of patients 21
No. of surgical levels 31
Age (yr) 55.4±12.4
Sex
 Male 11 (52.4)
 Female 10 (47.6)
Body mass index (kg/m2) 23.7±1.6
Presence of comorbiditiesa) 14 (66.7)
Presence of osteoporosis 8 (38.1)
Presenting symptoms
 Sensory disturbances only 15 (71.4)
 Combined sensory and motor disturbances 6 (28.6)
Follow-up period (mo) 14.8±6.7

Values are presented as number, mean ± standard deviation, or number (%).

a) Age-related health disorders in modified 5-item frailty index: diabetes mellitus, hypertension, chronic obstructive pulmonary disease or recent pneumonia, congestive heart failure, and history of cerebral infarction.

Table 2
Perioperative findings
Variable Measurement value
BE-PCF operative indication
 Foraminal stenosis with osteophyte 13 (42.0)
 Cervical disc herniation 9 (29.0)
 Combined osteophyte and disc herniation 9 (29.0)
Operative levels
 C3–C4 3 (9.6)
 C4–C5 6 (19.4)
 C5–C6 18 (58.1)
 C6–C7 4 (12.9)
Affected side
 Left 16 (51.6)
 Right 15 (48.4)
No. of surgical levels
 Single level 11 (52.4)
 Two levels 10 (47.6)
Operative time per level (min) 79.8±27.5
Intraoperative blood loss (mL) 140.5±48.1
Hospital stay (day) 5.2±1.8
Complications
 Wrong-level 1 (3.2)
 Dural tears 0 (0)
 Neurological deficit 1 (4.7)
 Infection 0 (0)

Values are presented as number (%) or mean±standard deviation.

BE-PCF, biportal endoscopic-posterior cervical foraminotomy.

Table 3
Clinical outcomes
Variable Preoperative Postoperative at discharge Postoperative at 6 mo Postoperative at last follow-up p-value
Visual Analog Scale scores
 Neck pain 6.9±1.1 3.1±0.7 2.6±0.6 2.5±0.7 <0.001
 Radiating pain 8.1±0.7 2.6±1.1 2.3±0.7 2.0±0.6 <0.001
Neck Disability Index 30.8±3.6 15.5±2.0 12.8±3.7 12.2±1.6 <0.001

Values are presented as mean±standard deviation.

Table 4
Radiological outcomes
Variable Preoperative Postoperative p-value
Cervical range of motion (°) 40.5±10.1 40.5±10.3 0.99
Segment range of motion (°) 13.1±4.4 13.8±5.7 0.18
Facet length (mm) 13.5±1.6 8.7±1.3 <0.001
Mid-foraminal diameter (mm) 4.2±0.8 6.5±1.0 <0.001
Distal-foraminal diameter (mm) 3.7±1.1 4.8±1.0 <0.001

Values are presented as mean±standard deviation.

Table 5
Correlation between approach side in BE-PCF and radiological parameters
Variable Overall (n=31) Left-side approach (n=16) Right-side approach (n=15) p-value
Facet resection rate (%) 34.6±7.7 35.9±6.4 33.3±8.9 0.35
Mid-foraminal diameter expansion rate (%) 60.4±34.1 57.1±41.9 63.9±23.9 0.58
Distal-foraminal diameter expansion rate (%) 34.7±27.5 38.3±31.1 30.8±23.5 0.46
Foraminal approach angle (°) 9.5±2.5 8.8±2.0 10.2±2.9 0.13

Values are presented as mean±standard deviation.

BE-PCF, biportal endoscopic-posterior cervical foraminotomy.

References

1. Rhee JM, Yoon T, Riew KD. Cervical radiculopathy. J Am Acad Orthop Surg 2007;15:486–94. https://doi.org/10.5435/00124635-200708000-00005
crossref pmid
2. Woods BI, Hilibrand AS. Cervical radiculopathy: epidemiology, etiology, diagnosis, and treatment. J Spinal Disord Tech 2015;28:E251–9. https://doi.org/10.1097/bsd.0000000000000284
crossref pmid
3. Kang KC, Jang TS, Jung CH. Cervical radiculopathy: focus on factors for better surgical outcomes and operative techniques. Asian Spine J 2022;16:995–1012. https://doi.org/10.31616/asj.2022.0445
crossref pmid pmc
4. Luyao H, Xiaoxiao Y, Tianxiao F, Yuandong L, Wang P. Management of cervical spondylotic radiculopathy: a systematic review. Global Spine J 2022;12:1912–24. https://doi.org/10.1177/21925682221075290
crossref pmid pmc
5. Bono CM, Ghiselli G, Gilbert TJ, et al. An evidence-based clinical guideline for the diagnosis and treatment of cervical radiculopathy from degenerative disorders. Spine J 2011;11:64–72. https://doi.org/10.1016/j.spinee.2010.10.023
crossref pmid
6. Taso M, Sommernes JH, Sundseth J, et al. Surgical versus nonsurgical treatment for cervical radiculopathy. NEJM Evid 2025;4:EVIDoa2400404. https://doi.org/10.1056/evidoa2400404
crossref pmid
7. Kim HJ, Nemani VM, Piyaskulkaew C, Vargas SR, Riew KD. Cervical radiculopathy: incidence and treatment of 1,420 consecutive cases. Asian Spine J 2016;10:231–7. https://doi.org/10.4184/asj.2016.10.2.231
crossref pmid pmc
8. Almasi A, Jafari S, Solouki L, Darvishi N. The best surgical treatment for cervical radiculopathy: a systematic review and network meta-analysis. Adv Biomed Res 2023;12:191. https://doi.org/10.4103/abr.abr_251_22
crossref pmid pmc
9. Mesregah MK, Baker M, Yoon C, et al. Radiographic risk factors for adjacent segment disease following anterior cervical discectomy and fusion (ACDF): a systematic review and meta-analysis. Global Spine J 2024;14:2183–200. https://doi.org/10.1177/21925682241237500
crossref pmid pmc
10. Sheng XQ, Wu TK, Liu H, Meng Y. Incidence of heterotopic ossification at 10 years after cervical disk replacement: a systematic review and meta-analysis. Spine (Phila Pa 1976) 2023;48:E203–15. https://doi.org/10.1097/brs.0000000000004674
crossref pmid pmc
11. Jagannathan J, Sherman JH, Szabo T, Shaffrey CI, Jane JA. The posterior cervical foraminotomy in the treatment of cervical disc/osteophyte disease: a single-surgeon experience with a minimum of 5 years’ clinical and radiographic follow-up. J Neurosurg Spine 2009;10:347–56. https://doi.org/10.3171/2008.12.spine08576
crossref pmid
12. Mummaneni PV, Bisson EF, Michalopoulos G, et al. Comparing posterior cervical foraminotomy with anterior cervical discectomy and fusion in radiculopathic patients: an analysis from the Quality Outcomes Database. J Neurosurg Spine 2024;41:56–68. https://doi.org/10.3171/2024.2.spine221280
crossref pmid
13. Kwon H, Park JY. The role and future of endoscopic spine surgery: a narrative review. Neurospine 2023;20:43–55. https://doi.org/10.14245/ns.2346236.118
crossref pmid pmc
14. Ahn Y, Lee S. Uniportal versus biportal endoscopic spine surgery: a comprehensive review. Expert Rev Med Devices 2023;20:549–56. https://doi.org/10.1080/17434440.2023.2214678
crossref pmid
15. Kang MS, Park HJ, Park SM, You KH, Ju WJ. Learning curve for biportal endoscopic posterior cervical foraminotomy determined using the cumulative summation test. J Orthop Surg Res 2023;18:146. https://doi.org/10.1186/s13018-023-03611-0
crossref pmid pmc
16. Heo DH, Ha JS, Jang JW. Biportal endoscopic posterior cervical foraminotomy for adjacent 2-level foraminal lesions using a single approach (sliding technique). Neurospine 2023;20:92–8. https://doi.org/10.14245/ns.2346144.072
crossref pmid pmc
17. Lee SH, Seo J, Jeong D, et al. Clinical outcomes and complications of unilateral biportal endoscopic posterior cervical foraminotomy: a systematic review and meta-analysis with a comparison to full-endoscopic posterior cervical foraminotomy. Neurospine 2024;21:807–19. https://doi.org/10.14245/ns.2448430.215
crossref pmid pmc
18. Fang H, Cui M, Zhao K, et al. Minimally invasive posterior cervical foraminotomy versus anterior cervical fusion and arthroplasty: systematic review and updated meta-analysis. Brain Spine 2024;4:102852. https://doi.org/10.1016/j.bas.2024.102852
crossref pmid pmc
19. Bydon M, Mathios D, Macki M, et al. Long-term patient outcomes after posterior cervical foraminotomy: an analysis of 151 cases. J Neurosurg Spine 2014;21:727–31. https://doi.org/10.3171/2014.7.spine131110
crossref pmid
20. Skovrlj B, Gologorsky Y, Haque R, Fessler RG, Qureshi SA. Complications, outcomes, and need for fusion after minimally invasive posterior cervical foraminotomy and microdiscectomy. Spine J 2014;14:2405–11. https://doi.org/10.1016/j.spinee.2014.01.048
crossref pmid
21. Kim JY, Hong HJ, Lee DC, Kim TH, Hwang JS, Park CK. Comparative analysis of 3 types of minimally invasive posterior cervical foraminotomy for foraminal stenosis, uniportal-, biportal endoscopy, and microsurgery: radiologic and midterm clinical outcomes. Neurospine 2022;19:212–23. https://doi.org/10.14245/ns.2142942.471
crossref pmid pmc
22. Park JH, Jun SG, Jung JT, Lee SJ. Posterior percutaneous endoscopic cervical foraminotomy and diskectomy with unilateral biportal endoscopy. Orthopedics 2017;40:e779–83. https://doi.org/10.3928/01477447-20170531-02
crossref pmid
23. Parker SL, Godil SS, Shau DN, Mendenhall SK, McGirt MJ. Assessment of the minimum clinically important difference in pain, disability, and quality of life after anterior cervical discectomy and fusion: clinical article. J Neurosurg Spine 2013;18:154–60. https://doi.org/10.3171/2012.10.spine12312
crossref pmid
24. Hong YH, Kim SK, Hwang J, et al. Water dynamics in unilateral biportal endoscopic spine surgery and its related factors: an in vivo proportional regression and proficiency-matched study. World Neurosurg 2021;149:e836–43. https://doi.org/10.1016/j.wneu.2021.01.086
crossref pmid
25. Lee HR, Park JM, Kim IH, Kim JH, Yang JH. Comparison of open microscopic and biportal endoscopic approaches in multi-level posterior cervical foraminotomy: radiological and clinical outcomes. J Clin Med 2024;14:164. https://doi.org/10.3390/jcm14010164
crossref pmid pmc
26. Lee DH, Lee HR, Seok SY, Choi JU, Park JM, Yang JH. Preoperative factors on loss of range of motion after posterior cervical foraminotomy. Medicina (Kaunas) 2024;60:1496. https://doi.org/10.3390/medicina60091496
crossref pmid pmc
27. Song KS, Kim P. Assessment of clinical and radiologic outcomes of biportal endoscopic posterior cervical inclinatory foraminotomy : a retrospective cohort study. J Korean Neurosurg Soc 2025;68:446–55. https://doi.org/10.3340/jkns.2024.0197
crossref pmid pmc
28. Zdeblick TA, Zou D, Warden KE, McCabe R, Kunz D, Vanderby R. Cervical stability after foraminotomy: a biomechanical in vitro analysis. J Bone Joint Surg Am 1992;74:22–7. https://doi.org/10.2106/00004623-199274010-00004
crossref pmid
29. Nakamura S, Taguchi M. Area of ostectomy in posterior percutaneous endoscopic cervical foraminotomy: images and mid-term outcomes. Asian Spine J 2017;11:968–74. https://doi.org/10.4184/asj.2017.11.6.968
crossref pmid pmc
30. Wu PH, Kim HS, Choi DJ, Gamaliel YH. Overview of tips in overcoming learning curve in uniportal and biportal endoscopic spine surgery. J Minim Invasive Spine Surg Tech 2021;6(Suppl 1):S84–96. https://doi.org/10.21182/jmisst.2020.00024
crossref


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine
88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
Tel: +82-2-3010-3530    Fax: +82-2-3010-8555    E-mail: asianspinejournal@gmail.com                
Korean Society of Spine Surgery
82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Korea
Tel: +82-31-966-3413    Fax: +82-2-831-3414    E-mail: office@spine.or.kr                

Copyright © 2026 by Korean Society of Spine Surgery.

Developed in M2PI

Close layer
prev next