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Asian Spine J > Volume 13(4); 2019 > Article
De Leo–Vargas, Muñoz–Romero, Mondragón–Soto, and Martínez–Anda: Locking Stand-Alone Cage Constructs for the Treatment of Cervical Spine Degenerative Disease


Study Design

Prospective case series study.


Description of the outcome of stand-alone cervical cages for single and multilevel cervical degenerative spine disease.

Overview of Literature

The aim of anterior cervical discectomy and fusion (ACDF) for cervical spine disease is to improve patient symptoms and spine stability and restore lordosis. Locking stand-alone cages were developed with the goal of minimizing soft tissue disruption anterior to the vertebrae and reducing the profile of the construct by avoiding an anterior plate, thereby maximizing ACDF benefits.


This study comprises a case series of patients surgically treated between July 2015 and February 2018 who received single or multilevel ACDF with a zero-profile stand-alone cervical cage. Surgical and clinical preoperative evaluation and surgical outcomes were evaluated using pre- and postoperative Nurick, Visual Analog Scale (VAS), Neck Disability Index (NDI), Japanese Orthopedic Association (JOA) score for myelopathy scales, cervical Cobb angles, postoperative surgical complications, and fusion and subsidence rates.


Fifty-three patients underwent ACDF; the mean age of these patients was 58.8 years, and their preoperative VAS, NDI, and JOA scores were 8.1, 31.6, and 15.3, respectively. The preoperative Cobb angle was 30.7°. Forty-five percent of patients had one-level, 54.7% had two-level, and 13.2% had three-level procedures. On preoperative magnetic resonance imaging, foraminal stenosis was present in 94.3% of patients, whereas medullar stenosis was present in 41.5%. The rate of complications was 5.7%: two patients had postoperative dysphagia (3.7%), and one patient had a surgical site hematoma. Mean postoperative follow-up time was 6.7 months; postoperative VAS, NDI, and JOA scores were 2.4, 15.9, and 15.8, respectively. Postoperative Cobb angle was 35.9°, fusion rate was 84.9%, and subsidence rate was 11.3%.


ACDF with zero-profile stand-alone cervical devices is an excellent option for cervical degenerative disc disease of one, two, and three levels, with similar results reported when using ACDF with either cage or plate.


Cervical spondylosis disorders are common problems in clinical practice. If supportive medical treatment and physical therapy fail to relieve clinical symptoms, or if neurological deficits are present, surgery is indicated [1]. Anterior cervical discectomy and fusion (ACDF) is the treatment of choice for several cervical spinal diseases [2]; the goal of this procedure is to improve patient symptoms and spine stability and restore lordosis.
Anterior plate construct (APC), as described by Smith and Robinson [3], has been the ‘gold standard’ technique for ACDF. Several modifications to the original procedure have been developed, such as locking stand-alone cages (LSC), with the intent to reduce soft tissue disruption anterior to the vertebrae as well as to reduce postoperative dysphagia and the profile of the construct, thereby maximizing ACDF benefits [4].
The present study describes the clinical and radiographic outcomes with LSC for single and multilevel cervical degenerative disease.

Materials and Methods

This study comprises a prospective case series of surgically treated patients between July 2015 and February 2018 to resolve cervical spine degenerative disease; all patients were surgically treated by single or multilevel ACDF at the Neurological Center of American British Cowdry Hospital in Mexico City, Mexico, by a single surgeon (RdL) with a zero-profile X-spine stand-alone cervical device. Investigation and ethical boards at American British Cowdry Hospital approved the study, and written informed consensts were obtained before surgery.

1. Patients

Inclusion criteria were: (1) signs and symptoms of cervical radiculopathy or spondylotic myelopathy, (2) cervical spondylosis confirmed using magnetic resonance imaging (MRI), and (3) follow-up of ≥3 months. Exclusion criteria were: (1) ossification of the posterior longitudinal ligament, (2) developmental stenosis, (3) invasive malignancy, (4) evidence of systemic or local infection, and (5) history of previous cervical spine surgery.

2. Clinical evaluation and outcome scores

Clinical preoperative evaluation and surgical outcomes were evaluated using pre- and postoperative Nurick and Visual Analog Scale (VAS) for neck and radicular pain as well as Neck Disability Index (NDI) and Japanese Orthopedic Association (JOA) score for myelopathy. Data were prospectively collected during the preoperative evaluation and also immediately collected after surgery as well as 3 months, 6 months, and 12 months after surgery.

3. Surgical technique

Patients were placed in the supine position with neck hyperextension; the surgical site was exposed via a standard anterior approach and microscopic anterior cervical discectomy was performed. After dural decompression, interbody fusion was performed using a zero-profile Irix-C cervical cage (X-spine Systems Inc., Miamisburg, OH, USA). The cages were filled with demineralized bone matrix for fusion.

4. Radiological evaluation

Anteroposterior, lateral, and flexion-extension cervical radiographs were obtained before and immediately after surgery, as well as at 3 and 12 months after surgery (Fig. 1). MRI evaluation was preoperatively performed in all patients. Signs of medullar and radicular compression, Modic changes, disc degeneration (classification adapted from Pfirrmann lumbar classification [5]), and myelopathy signs were analyzed.
Cervical Cobb angles were measured pre- and postoperatively as the angle formed between a line parallel to the inferior endplate of C2 and a line drawn parallel to the inferior endplate of C7 [6]. Postoperative radiographs were analyzed for fusion and subsidence. Fusion was defined as (1) movement <2° in postoperative flexion-extension radiographs, (2) presence of trabeculae bridging bone formation at the anterior and/or posterior cortex of the involved vertebral bodies (Fig. 2B); and (3) absence of radiolucency through the fusion levels. Subsidence was defined as ≥3 mm reduction in the segmental height in postoperative images [1].

5. Statistical analysis

Descriptive statistics were used to describe epidemiological and clinical data. Fisher’s χ2, Kruskall–Wallis and Student t-tests were used for univariate analysis. Statistical analyses were performed using IBM SPSS Statistics ver. 19.0 (IBM Corp., Armonk, NY, USA).


1. Patients

Our analysis included a total of 53 patients who met the inclusion criteria for this study. The average age of the patients was 58.8 years; they had cervical or radicular symptoms for a period of approximately 14.8 months, and a follow-up time of 6.7 months. Thirty-four patients (64%) were female, with a female to male ratio of 1.78:1 (Table 1).
In preoperative clinical evaluation, 32.1% of patients reported cervical pain, 11.3% reported radicular pain, and 56.6% reported both; mean preoperative VAS pain score was 8.1, with a mean NDI score of 31.6 (81.1% of patients had at least moderate disability). Myelopathic symptoms were present in 56.6% of patients; 41.5% of patients had Nurick 1 myelopathy and a mean JOA score of 15.3 (Table 2).
Multilevel disc degeneration was present in 54.7% of patients; seven patients (13.2%) had three-level disease. Forty-two patients (79.2%) had C5–6 fusion as part of single or multilevel disease. All patients had at least Pfirrmann grade 2 disc degeneration; 96.2% of patients had disc degeneration of ≥Pfirrmann 3. Eight patients (15.1%) had listhesis, 94.3% had at least partial foraminal stenosis, and 44% showed Modic changes in at least one cervical level (Table 1).
Twenty-four patients (41.5%) had at least partial central cervical stenosis; only 24.5% had signs of medullar myelopathy on MRI. On lateral X-ray, the mean preoperative Cobb angle was 30.7°; 79.2% of patients had lordotic preoperative cervical curvature (Table 1).

2. Clinical outcome

Three patients (5.7%) developed postoperative complications. Two of these three patients (3.7%) developed transient dysphagia, while the other patient had retropharyngeal hematoma, which was observed in postoperative X-ray and did not compromise the airway; therefore, no further treatment was required. No significant differences were found between single or multilevel disease (Table 2).
On follow-up, all patients reported at least partial improvement in functional status and pain scale; VAS score improved from 8.1 to 2.4, NDI score improved from 31.6 to 15.9, and JOA scale improved from 15.3 to 15.8. All scales exhibited statistically significant improvement (p≤0.001). No significant difference was found between single versus multilevel disease in clinical outcome (VAS or NDI); however, patients with multilevel disease had better improvement in postoperative JOA (p=0.016) (Table 2).

3. Radiological outcome

Fusion was documented in 84.9% of patients (Fig. 2A); 95.8% of patients with single level disease achieved postoperative fusion versus 75.9% of patients with multilevel disease. There was a significant difference between the single and multilevel disease groups (p=0.04), but no difference between two- or three-level disease groups with regard to fusion indices. No significant difference was found between fusion and no-fusion groups in NDI score (16.3 versus 13.5, p=0.45) or VAS scale (2.4 versus 2.3, p=0.74) (Table 2).
Cage subsidence was found in six patients (11.3%) with no significant difference between single or multilevel procedures. The cervical level that had higher indices of pseudoarthrosis and subsidence was C5–6 (88.8% of fusion and 13.8% of subsidence). No significant difference was found between subsidence and no-subsidence groups in NDI score (14.7 versus 16.1, p=0.5) or VAS scale (2.3 versus 2.4, p=0.21) (Table 2).
There was a mean 5.7° change in cervical spine curvature, including a postoperative improvement in Cobb angle from 30.7° to 35.9°, which was a significant difference (p≤0.001) (Fig. 1); No significant difference was found between single or multilevel disease in cervical angle improvement (5.2° versus 6.1°, p=0.56) (Table 2).
We observed that nine patients (17%) had adjacent segment changes in follow-up studies, but none had symptomatology attributable to the findings identified using imaging (Fig. 2B). No significant differences were found in adjacent segment changes between patients with single level or multilevel procedures. At follow-up, there was no significant difference in clinical outcome between patients with adjacent segment changes and patients with any findings in sequential image studies (Table 2).


APCs for ACDF are effective in achieving immediate stability, improving cervical sagittal alignment, and increasing fusion rates, with a low profile of current anterior plating systems. More recently, there has been an increase in the use of the LSC, which does not require an anterior plate and minimizes cervical soft tissue disruption, thereby reducing the profile of the construct [4]. Studies have demonstrated the safety and efficacy of three-level ACDF with cages and plate fixation; however, complications associated with plate fixation (e.g., breakage, loosening of screws, screw penetration to endplate, triangle fracture, and visceral and vascular structural injuries) have been reported with multilevel ACDF [7]. Stand-alone cages appear to overcome these limitations of anterior plating, but there is disagreement regarding the use of stand-alone cages with respect to subsidence, cage migration, loss of cervical lordosis and fused segment angle, and relatively low fusion rate [8]. Some studies have indicated that zero-profile LSC has a better clinical effect on cervical spondylosis, with fewer invasive surgical treatments than APC [9]. The surgical procedure for LSC is very simple and relatively short; it primarily requires tightening of screws after placement [10]. The operative time is significantly greater and blood loss is significantly higher with APC, compared with LSC, in single and multilevel procedures [11-13]. Surgical exposure and steps for plate insertion are time-consuming and increase soft tissue dissection, blood loss, and surgical time. We achieved excellent results with LSC for single and multilevel disease (Fig. 1), with significant improvement in NDI, JOA, and VAS scores. Clinical results in pain and functional scales between groups were similar in this case series; notably, a better outcome with regard to JOA score was observed in multilevel disease, given that that group had a higher incidence of central canal compromise. Few previous reports have addressed the comparison between single and multilevel cervical disease in the same case series. In this study, we found that clinical and radiological outcomes were comparable between the groups.
APC might pose a substantial risk of hardware-related complications, such as plate dislodgement, soft tissue injury, tracheoesophageal lesions, and dysphagia [14,15]. Dysphagia is recognized as the earliest complaint after ACDF using an additional anterior plate. The reported incidence of transient dysphagia after ACDF ranges from 2%–71%, and that of chronic dysphagia ranges from 3%–21% [14,16-18]. Studies have found that LSC has a lower risk of dysphagia as a complication, compared with APC, in postoperative and follow-up periods [4]. Li et al. [18] reported a 6.8% incidence of postoperative dysphagia, as well as 2.8% incidence at 3 months postoperatively. We observed a 3.7% incidence of transient dysphagia that lasted 4–7 days, less than that reported with the APC technique; notably, no patients exhibited permanent dysphagia. Dysphagia following instrumentation with APC implies that plate design may have an effect on soft tissue structures; possible explanations include postoperative soft tissue edema, esophageal injury, postoperative hematoma, and adhesive formations around implanted cervical plates [19]. Low-profile implants are completely contained in the intervertebral space, avoiding mechanical stimulus to the esophagus; furthermore, the operative procedure is simpler, with reduced retraction of the esophagus, diminishing the risk of postoperative dysphagia [20]. Patients undergoing three-level fusion have significantly higher incidence of postoperative dysphagia than those undergoing one- or two-level fusions, because of the iatrogenic irritation to soft tissues during surgical exposure [21]; therefore, we recommend gentle dissection of cervical tissues and adequate surgical level planning to reduce the incidence of postoperative complications related to the procedure.
Only stable bony fusion prevents delayed kyphotic deformity with concomitant foraminal stenosis causing root compression and neck pain. When single-level ACDF is performed, 83%–100% of radiographic fusion is reported with both techniques [18]. In multilevel cervical disease, bony fusion rates and postoperative sagittal balance have varied among studies as well as on the basis of parameters used for evaluation; fusion rates for multilevel cervical disc degenerative disease vary from 78%–100% [7,22]. Chen et al. [7] reported similar rates of fusion between both techniques (APC versus LSC) in multilevel cervical disease (95.7% versus 92.3%). We observed total fusion in 84.9% of patients (Fig. 2A), with significantly higher rates of fusion in the single level procedure than in multilevel surgery (95.8% versus 75.9%); however, there was no significant difference in clinical outcome between both groups. Long-term results must be evaluated, and other factors beyond technique should be considered during evaluation; these include bone quality of the patients, implant used, distraction achieved by cage usage, and grade of subchondral bone exposure during the meticulous preparation of the endplate for fusion.
During the process of bone remodeling, the settlement of the cage of <2 mm into the vertebral bodies until fusion is to be expected; subsidence is defined as the sinking of an object with a greater elasticity modulus (cage) into an object with a lower elasticity modulus (vertebral body) [1]. If the cage subsides into the vertebral body with disc space collapse, foraminal height and cervical alignment are not restored [8,14]. Subsidence has been reported in 9.3 to 62.5% of cervical segments analyzed, and it often occurs within 3 months after surgery [8,14,22-24]. Although subsidence does not appear to affect clinical outcomes, this must be evaluated in long-term studies [7,25-27]. We observed cage subsidence in 11.3% of our patients, that was within the range reported in previous series. In a one-level procedure, no significant difference was present between the two techniques, and subsidence risk increased with the number of levels treated; it was more common in C5–6 and C6–7 levels, as we observed in the present study [1,4]. With a greater increase in interbody height, the risk for subsidence also increases, suggesting that oversized cages may be a risk factor for subsidence [1]; we found no difference in the incidence of subsidence between single and multilevel procedures. Nevertheless, the long-term clinical outcome of patients with subsidence remains satisfactory, as the disc height of treated level at final follow-up remains significantly greater that that before surgery; moreover, after fusion, subsidence does not progress [1,18,28]. Kao et al. [1] reported no subsidence-related symptoms that required treatment during follow-up in a series of patients treated with LSC for cervical disc disease. In our series, we found no difference in clinical outcome evaluated by NDI and VAS between subsidence and no-subsidence groups. There are no objective parameters for use in determining the correct size cage or predicting clinical outcome [1,29].
Sagittal misalignment will cause an increased stress distribution on internal fixation devices, as well as cervical instability, postoperative axial pain, and deterioration of neurological deficit; these parameters influence functional recovery [18]. In addition, maintenance of cervical alignment is important because malalignment leads to adjacent segmental degeneration of the fused segment and can also cause worsening of long-term outcomes [22]. We observed improvement in cervical lordosis of 5.7° without significant difference between single and multilevel disease. Both APC and LSC improved local and global sagittal balance in single and multilevel cervical degenerative disease; some studies have shown no significant differences in cervical angles between these techniques [4,15].
Incidence of adjacent segment disease following ACDF has been reported in approximately 25% of patients [30]. Peri-plate ossification has been previously described as a finding following arthrodesis with anterior cervical plate; notably, there is a higher incidence of adjacent segment degeneration if an additional plate is placed close to an adjacent disc space [15]. With LSC, the incidence of adjacent segment disease is reported from 2% to 30%% at follow-up [18]. We found adjacent segment changes in sequential postoperative studies in nine patients (17%), with no difference between single and multilevel disease; moreover, there was no difference in clinical outcome (Fig. 2B). These findings suggest that even with the LSC technique, there is a significant risk of adjacent segment disease, and additional follow-up is needed to evaluate clinical outcome related to adjacent segment changes in imaging studies.
Case-control studies involving patients surgically treated with ACDF via LSC versus APC technique are needed; furthermore, long-term consequences of complications (e.g., subsidence, sagittal misalignment, adjacent segment disease, and pseudoarthrosis) must be addressed for further analysis of clinical and radiological results.


Stand-alone ACDF with zero-profile stand-alone cervical devices is an excellent option for cervical degenerative disc disease of one, two, and three levels; similar results were reported with ACDF using either a cage or a plate.

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Fig. 1.
Preoperative and postoperative plain radiographs of cervical spine in patients with locking stand-alone cage treatment. (A) Preoperative X-ray displayed degeneration and abnormal physiologic curvature of the cervical spine. (B) Postoperative X-ray displayed good internal fixation and improvement of physiological curvature.
Fig. 2.
(A) Presence of trabeculae bridging bone formation at the posterior cortex between surgically treated segments (arrow). (B) Adjacent segment changes above surgically treated segments (arrow).
Table 1.
Clinical and epidemiological data
Characteristic Value
No. of patients 53
Age (yr) 58.8
 Female 34 (64.2)
 Male 19 (35.8)
Time with symptoms (mo) 14.8±16
 Single level 24 (45.3)
 Two levels 22 (41.5)
 Three levels 7 (13.2)
Type of pain
 Cervical 17 (32.1)
 Radicular 6 (11.3)
 Both 30 (50.6)
Nurick score
 0 23 (43.4)
 1 22 (41.5)
 2 7 (13.2)
 3 1 (1.9)
Radiological findings
  1 0
  2 2 (3.8)
  3 25 (47.2)
  4 24 (45.3)
  5 2 (3.8)
 Listhesis 8 (15.1)
 Foraminal stenosis 50 (94.3)
 Central stenosis 24 (41.5)
 Myelopathy 13 (24.5)
 Cobbs angle (°) 30.7±14.2
 Cervical myelopathy 13 (24.5)
 Modic changes
  0 35 (66.0)
  1 15 (28.3)
  2 3 (5.7)

Values are presented as number, number (%), or mean±standard deviation.

a) C4–5, 4 (7.5%); C5–6, 16 (30.2%); C6–7, 5 (9.4%); C3–5, 2 (3.8%); C4–6, 8 (15.1%); C5–7, 11 (20.8%); C4–7, 7 (13.2%).

Table 2.
Clinical and surgical outcome
Variable Mean±standard deviation p-value
NDI (%)
 Preop 31.6±11.6 <0.001
 Postop 15.9±8.5
 Single level 13.9±5.7 0.88
 Multilevel 17.6±10.1
VAS score
 Preop 8.1±1.4 <0.001
 Postop 2.4±0.8
 Single level 2.2±0.8 0.3
 Multilevel 2.5±0.7
JOA score
 Preop 15.3±1.8 <0.001
 Postop 15.9±1.2
 Single level 16.3±0.8 0.016
 Multilevel 15.6±1.3
Cobb angle (°)
 Preop 30.7±14.2 <0.001
 Postop 35.9±15.6
 Single level 29.8±15.6 0.64
 Multilevel 31.4±13.2
Cobb angle change (°) 5.77±6.5
 Single level 5.2±4.5 0.56
 Multilevel 6.1±7.8
Fusion rate (%) 84.5
 Single level 95.8 0.04
 Multilevel 75.9
 NDI fusion 16.3±8.9 0.45
 NDI no fusion 13.5±6
 VAS fusion 2.4±0.8 0.74
 VAS no fusion 2.3±0.9
Subsidence rate (%) 11.3
 Single level 8.3 0.53
 Multilevel 13.8
 NDI subsidence 14±7 0.5
 NDI no subsidence 16.1±8.7
 VAS subsidence 2.3±0.5 0.21
 VAS no subsidence 2.4±0.8
Surgical complications rate (%) 5.7
 Single level 8.3 0.44
 Multilevel 3.4
AS changes (%) 17
 Single level 12.5 0.4
 Multilevel 26
 NDI AS 14.8±10 0.5
 NDI no AS 16.1±8.3
 VAS AS 2.3±0.8 0.9
 VAS no AS 2.4±0.8

NDI, Neck Disability Index; Preop, preoperative; Postop, postoperative; VAS, Visual Analog Scale; JOA, Japanese Orthopedics Association; AS, adjacent segment.


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