1. Lee MJ, Cizik AM, Hamilton D, Chapman JR. Predicting surgical site infection after spine surgery: a validated model using a prospective surgical registry. Spine J 2014 14:2112–7.
2. Lonjon G, Dauzac C, Fourniols E, et al. Early surgical site infections in adult spinal trauma: a prospective, multicentre study of infection rates and risk factors. Orthop Traumatol Surg Res 2012 98:788–94.
4. Zhou J, Wang R, Huo X, Xiong W, Kang L, Xue Y. Incidence of surgical site infection after spine surgery: a systematic review and meta-analysis. Spine (Phila Pa 1976) 2020 45:208–16.
5. Veeravagu A, Patil CG, Lad SP, Boakye M. Risk factors for postoperative spinal wound infections after spinal decompression and fusion surgeries. Spine (Phila Pa 1976) 2009 34:1869–72.
6. Koutsoumbelis S, Hughes AP, Girardi FP, et al. Risk factors for postoperative infection following posterior lumbar instrumented arthrodesis. J Bone Joint Surg Am 2011 93:1627–33.
7. Kuhns BD, Lubelski D, Alvin MD, et al. Cost and quality of life outcome analysis of postoperative infections after subaxial dorsal cervical fusions. J Neurosurg Spine 2015 22:381–6.
8. Bernatz JT, Anderson PA. Thirty-day readmission rates in spine surgery: systematic review and meta-analysis. Neurosurg Focus 2015 39:E7.
10. Atkinson RA, Jones A, Ousey K, Stephenson J. Management and cost of surgical site infection in patients undergoing surgery for spinal metastasis. J Hosp Infect 2017 95:148–53.
11. Blumberg TJ, Woelber E, Bellabarba C, Bransford R, Spina N. Predictors of increased cost and length of stay in the treatment of postoperative spine surgical site infection. Spine J 2018 18:300–6.
12. Godil SS, Parker SL, O’Neill KR, Devin CJ, McGirt MJ. Comparative effectiveness and cost-benefit analysis of local application of vancomycin powder in posterior spinal fusion for spine trauma: clinical article. J Neurosurg Spine 2013 19:331–5.
13. Agarwal N, Agarwal P, Querry A, et al. Implementation of an infection prevention bundle and increased physician awareness improves surgical outcomes and reduces costs associated with spine surgery. J Neurosurg Spine 2018 29:108–14.
14. Deng H, Chan AK, Ammanuel S, et al. Risk factors for deep surgical site infection following thoracolumbar spinal surgery. J Neurosurg Spine 2019 32:292–301.
15. Meng F, Cao J, Meng X. Risk factors for surgical site infections following spinal surgery. J Clin Neurosci 2015 22:1862–6.
16. Schuster JM, Rechtine G, Norvell DC, Dettori JR. The influence of perioperative risk factors and therapeutic interventions on infection rates after spine surgery: a systematic review. Spine (Phila Pa 1976) 2010 35(9 Suppl): S125–37.
17. Radcliff KE, Neusner AD, Millhouse PW, et al. What is new in the diagnosis and prevention of spine surgical site infections. Spine J 2015 15:336–47.
18. Ogihara S, Yamazaki T, Shiibashi M, et al. Risk factor analysis of deep surgical site infection after posterior instrumented fusion surgery for spinal trauma: a multicenter observational study. World Neurosurg 2020 134:e524–9.
20. Anderson PA, Savage JW, Vaccaro AR, et al. Prevention of surgical site infection in spine surgery. Neurosurgery 2017 80:S114–23.
21. Blood AG, Sandoval MF, Burger E, Halverson-Carpenter K. Risk and protective factors associated with surgical infections among spine patients. Surg Infect (Larchmt) 2017 18:234–49.
22. Olsen MA, Nepple JJ, Riew KD, et al. Risk factors for surgical site infection following orthopaedic spinal operations. J Bone Joint Surg Am 2008 90:62–9.
23. Butler JS, Wagner SC, Morrissey PB, et al. Strategies for the prevention and treatment of surgical site infection in the lumbar spine. Clin Spine Surg 2018 31:323–30.
24. McGirt MJ, Parker SL, Lerner J, Engelhart L, Knight T, Wang MY. Comparative analysis of perioperative surgical site infection after minimally invasive versus open posterior/transforaminal lumbar interbody fusion: analysis of hospital billing and discharge data from 5,170 patients. J Neurosurg Spine 2011 14:771–8.
25. Haleem A, Chiang HY, Vodela R, et al. Risk factors for surgical site infections following adult spine operations. Infect Control Hosp Epidemiol 2016 37:1458–67.
26. Ning J, Wang J, Zhang S, Sha X. Nasal colonization of Staphylococcus aureus and the risk of surgical site infection after spine surgery: a meta-analysis. Spine J 2020 20:448–56.
27. Higgins M, Bommireddy R, Shivji F, Al-Shukri J, Billson J. Impact of MSSA screening on rates of surgical site infection following lumbar spine surgery. Eur Spine J 2018 27:2457–62.
28. Thakkar V, Ghobrial GM, Maulucci CM, et al. Nasal MRSA colonization: impact on surgical site infection following spine surgery. Clin Neurol Neurosurg 2014 125:94–7.
29. Bode LG, Kluytmans JA, Wertheim HF, et al. Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med 2010 362:9–17.
31. Chan AK, Ammanuel SG, Chan AY, et al. Chlorhexidine showers are associated with a reduction in surgical site infection following spine surgery: an analysis of 4266 consecutive surgeries. Neurosurgery 2019 85:817–26.
32. Savage JW, Weatherford BM, Sugrue PA, et al. Efficacy of surgical preparation solutions in lumbar spine surgery. J Bone Joint Surg Am 2012 94:490–4.
34. Celik SE, Kara A. Does shaving the incision site increase the infection rate after spinal surgery? Spine (Phila Pa 1976) 2007 32:1575–7.
35. Pahys JM, Pahys JR, Cho SK, et al. Methods to decrease postoperative infections following posterior cervical spine surgery. J Bone Joint Surg Am 2013 95:549–54.
36. Shaffer WO, Baisden JL, Fernand R, Matz PG. North American Spine Society. An evidence-based clinical guideline for antibiotic prophylaxis in spine surgery. Spine J 2013 13:1387–92.
37. Petignat C, Francioli P, Harbarth S, et al. Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study. Spine (Phila Pa 1976) 2008 33:1919–24.
38. Barker FG 2nd. Efficacy of prophylactic antibiotic therapy in spinal surgery: a meta-analysis. Neurosurgery 2002 51:391–400.
39. Appelbaum PC. The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus. Clin Microbiol Infect 2006 12(Suppl 1): 16–23.
40. Rubinstein E, Findler G, Amit P, Shaked I. Perioperative prophylactic cephazolin in spinal surgery: a double-blind placebo-controlled trial. J Bone Joint Surg Br 1994 76:99–102.
41. Steinberg JP, Braun BI, Hellinger WC, et al. Timing of antimicrobial prophylaxis and the risk of surgical site infections: results from the trial to reduce antimicrobial prophylaxis errors. Ann Surg 2009 250:10–6.
42. Riley LH 3rd. Prophylactic antibiotics for spine surgery: description of a regimen and its rationale. J South Orthop Assoc 1998 7:212–7.
43. Hellbusch LC, Helzer-Julin M, Doran SE, et al. Single-dose vs multiple-dose antibiotic prophylaxis in instrumented lumbar fusion: a prospective study. Surg Neurol 2008 70:622–7.
44. Kakimaru H, Kono M, Matsusaki M, Iwata A, Uchio Y. Postoperative antimicrobial prophylaxis following spinal decompression surgery: is it necessary? J Orthop Sci 2010 15:305–9.
45. Sheffield CW, Sessler DI, Hunt TK, Scheuenstuhl H. Mild hypothermia during halothane-induced anesthesia decreases resistance to Staphylococcus aureus dermal infection in guinea pigs. Wound Repair Regen 1994 2:48–56.
46. Sheffield CW, Sessler DI, Hunt TK. Mild hypothermia during isoflurane anesthesia decreases resistance to E. coli dermal infection in guinea pigs. Acta Anaesthesiol Scand 1994 38:201–5.
47. Kurz A, Sessler DI, Lenhardt R. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization: study of Wound Infection and Temperature Group. N Engl J Med 1996 334:1209–15.
49. Ghobrial GM, Cadotte DW, Williams K Jr, Fehlings MG, Harrop JS. Complications from the use of intrawound vancomycin in lumbar spinal surgery: a systematic review. Neurosurg Focus 2015 39:E11.
50. Ghobrial GM, Thakkar V, Andrews E, et al. Intraoperative vancomycin use in spinal surgery: single institution experience and microbial trends. Spine (Phila Pa 1976) 2014 39:550–5.
51. Chiang HY, Herwaldt LA, Blevins AE, Cho E, Schweizer ML. Effectiveness of local vancomycin powder to decrease surgical site infections: a meta-analysis. Spine J 2014 14:397–407.
52. Theologis AA, Demirkiran G, Callahan M, Pekmezci M, Ames C, Deviren V. Local intrawound vancomycin powder decreases the risk of surgical site infections in complex adult deformity reconstruction: a cost analysis. Spine (Phila Pa 1976) 2014 39:1875–80.
53. Sweet FA, Roh M, Sliva C. Intrawound application of vancomycin for prophylaxis in instrumented thoracolumbar fusions: efficacy, drug levels, and patient outcomes. Spine (Phila Pa 1976) 2011 36:2084–8.
55. Evaniew N, Khan M, Drew B, Peterson D, Bhandari M, Ghert M. Intrawound vancomycin to prevent infections after spine surgery: a systematic review and meta-analysis. Eur Spine J 2015 24:533–42.
56. Bakhsheshian J, Dahdaleh NS, Lam SK, Savage JW, Smith ZA. The use of vancomycin powder in modern spine surgery: systematic review and meta-analysis of the clinical evidence. World Neurosurg 2015 83:816–23.
57. Kang DG, Holekamp TF, Wagner SC, Lehman RA Jr. Intrasite vancomycin powder for the prevention of surgical site infection in spine surgery: a systematic literature review. Spine J 2015 15:762–70.
58. Tubaki VR, Rajasekaran S, Shetty AP. Effects of using intravenous antibiotic only versus local intrawound vancomycin antibiotic powder application in addition to intravenous antibiotics on postoperative infection in spine surgery in 907 patients. Spine (Phila Pa 1976) 2013 38:2149–55.
59. Martin JR, Adogwa O, Brown CR, et al. Experience with intrawound vancomycin powder for spinal deformity surgery. Spine (Phila Pa 1976) 2014 39:177–84.
60. Gans I, Dormans JP, Spiegel DA, et al. Adjunctive vancomycin powder in pediatric spine surgery is safe. Spine (Phila Pa 1976) 2013 38:1703–7.
61. Adogwa O, Elsamadicy AA, Sergesketter A, et al. Prophylactic use of intraoperative vancomycin powder and postoperative infection: an analysis of microbiological patterns in 1200 consecutive surgical cases. J Neurosurg Spine 2017 27:328–34.
62. Hey HW, Thiam DW, Koh ZS, et al. Is intraoperative local vancomycin powder the answer to surgical site infections in spine surgery? Spine (Phila Pa 1976) 2017 42:267–74.
63. Von Eckardstein KL, Dohmes JE, Rohde V. Use of closed suction devices and other drains in spinal surgery: results of an online, Germany-wide questionnaire. Eur Spine J 2016 25:708–15.
64. Zijlmans JL, Buis DR, Verbaan D, Vandertop WP. Wound drains in non-complex lumbar surgery: a systematic review. Bone Joint J 2016 98-B:984–9.
65. Patel SB, Griffiths-Jones W, Jones CS, et al. The current state of the evidence for the use of drains in spinal surgery: systematic review. Eur Spine J 2017 26:2729–38.
66. Fay MF. Drainage systems: their role in wound healing. AORN J 1987 46:442–55.
67. Pennington Z, Lubelski D, Molina C, Westbroek EM, Ahmed AK, Sciubba DM. Prolonged post-surgical drain retention increases risk for deep wound infection after spine surgery. World Neurosurg 2019 130:e846–53.
68. Andrew Glennie R, Dea N, Street JT. Dressings and drains in posterior spine surgery and their effect on wound complications. J Clin Neurosci 2015 22:1081–7.
69. Yamada T, Yoshii T, Egawa S, et al. Drain tip culture is not prognostic for surgical site infection in spinal surgery under prophylactic use of antibiotics. Spine (Phila Pa 1976) 2016 41:1179–84.
70. Ovadia D, Drexler M, Kramer M, Herman A, Lebel DE. Closed wound subfascial suction drainage in posterior fusion surgery for adolescent idiopathic scoliosis: a prospective randomized control study. Spine (Phila Pa 1976) 2019 44:377–83.
71. Herrick DB, Tanenbaum JE, Mankarious M, et al. The relationship between surgical site drains and reoperation for wound-related complications following posterior cervical spine surgery: a multicenter retrospective study. J Neurosurg Spine 2018 29:628–34.
74. Chen YC, Zhang L, Li EN, et al. One or two drains for the treatment of surgical site infections after lumbar spine surgery. World Neurosurg 2018 116:e18–25.
75. Alcala-Marquez C, Torrealba R, Mehbod AA, Dawson JM, Dressel TD, Transfeldt EE. Recurrent surgical site infections in the spine after treatment with the vacuum-assisted Closure (VAC) system. Clin Spine Surg 2018 31:351–5.
76. Ousey KJ, Atkinson RA, Williamson JB, Lui S. Negative pressure wound therapy (NPWT) for spinal wounds: a systematic review. Spine J 2013 13:1393–405.
79. Kale M, Padalkar P, Mehta V. Vacuum-assisted closure in patients with post-operative infections after instrumented spine surgery: a series of 12 cases. J Orthop Case Rep 2017 7:95–100.
80. van Rhee MA, de Klerk LW, Verhaar JA. Vacuum-assisted wound closure of deep infections after instrumented spinal fusion in six children with neuromuscular scoliosis. Spine J 2007 7:596–600.
81. Canavese F, Marengo L, Corradin M, et al. Deep postoperative spine infection treated by negative pressure therapy in patients with progressive spinal deformities. Arch Orthop Trauma Surg 2018 138:463–9.
82. Adogwa O, Fatemi P, Perez E, et al. Negative pressure wound therapy reduces incidence of postoperative wound infection and dehiscence after long-segment thoracolumbar spinal fusion: a single institutional experience. Spine J 2014 14:2911–7.
83. Ridwan S, Grote A, Simon M. Safety and efficacy of negative pressure wound therapy for deep spinal wound infections after dural exposure, durotomy, or intradural surgery. World Neurosurg 2020 134:e624–30.
85. Abboud EC, Settle JC, Legare TB, Marcet JE, Barillo DJ, Sanchez JE. Silver-based dressings for the reduction of surgical site infection: review of current experience and recommendation for future studies. Burns 2014 40(Suppl 1): S30–9.
87. Epstein NE. Do silver-impregnated dressings limit infections after lumbar laminectomy with instrumented fusion? Surg Neurol 2007 68:483–5.
88. Little JW, Bickley HC, Daugherty WB, Bickley C. Effect of aquaphor ointment on wound healing. J Dent Res 1972 51:1672–4.
89. Smack DP, Harrington AC, Dunn C, et al. Infection and allergy incidence in ambulatory surgery patients using white petrolatum vs bacitracin ointment: a randomized controlled trial. JAMA 1996 276:972–7.
93. Matatov T, Reddy KN, Doucet LD, Zhao CX, Zhang WW. Experience with a new negative pressure incision management system in prevention of groin wound infection in vascular surgery patients. J Vasc Surg 2013 57:791–5.
94. Nickl S, Steindl J, Langthaler D, et al. First experiences with incisional negative pressure wound therapy in a high-risk poststernotomy patient population treated with pectoralis major muscle flap for deep sternal wound infection. J Reconstr Microsurg 2018 34:1–7.